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About this site:
Credits: PURPOSE: To increase the availability of scientific knowledge related to the distribution in human brain of receptor populations thought to be involved in psychiatric and neurologic disorders, that are the target of efforts to develop radioligands for use in studies employing positron emission tomography and SPECT. We are in possession of a large and unique data base of postmortem human brain autoradiographic receptor studies that map in high resolution the level of binding in slide mounted section suitable for comparison with lower resolution images generated by in vivo scans using PET or SPECT. Investigators can use their own PET or SPECT scans to compare to our postmortem images and to our PET studies to determine the comparability of distribution as an anatomical validation of new ligands.

Postmortem brain autoradiography images provided by Victoria Arango, Ph.D., Mark D. Underwood, Ph.D. and J. John Mann, M.D.

PET and MRI images provided by Ramin V. Parsey, M.D., Ph.D., Jeffrey Miller, M.D. and J. John Mann, M.D.

All research was performed at the New York State Psychiatric Institute (NYSPI) and Columbia University.

Content supported by funding from the National Institutes of Mental Health and the Diane Goldberg Foundation

Authors and website design by:

David Andrews and Shai Mann-Robison

Rebuilt by SM-R Last Updated: July 7, 2019 by mjb

Ligand CoregistrationA side by side presentation of Autoradiogram, PET and MRI images.
Images Library View six types of autoradiogram images and the corresponding MRI and PET images.
Overlayed PET & MRI Look at PET and MRI images overlayed with varying opacities.